Opportunities for use of human iPS cells in predictive toxicology

Clin Pharmacol Ther. 2011 May;89(5):754-8. doi: 10.1038/clpt.2011.9. Epub 2011 Mar 23.


Toxicity assessment is a major challenge for cost-effective drug development, and there is great need for better tools to accurately predict adverse drug reactions. Technological advances are empowering new cell-based assays for predictive toxicology, and these assays are critically dependent on the cell source. Here we describe the properties of human induced pluripotent stem (iPS) cells that make them a promising cell source for toxicity assessment and highlight progress to date and important roadblocks remaining.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug-Related Side Effects and Adverse Reactions / diagnosis
  • Drug-Related Side Effects and Adverse Reactions / pathology
  • Humans
  • Induced Pluripotent Stem Cells* / cytology
  • Predictive Value of Tests
  • Toxicology / methods*
  • Toxicology / trends