Use of controlled low dose gamma irradiation to sterilize allograft tendons for ACL reconstruction: biomechanical and clinical perspective

Cell Tissue Bank. 2012 Jun;13(2):217-23. doi: 10.1007/s10561-011-9251-7. Epub 2011 Mar 23.


As reviewed here, numerous biomechanical and clinical studies support the use of controlled, low temperature irradiation of allograft tendons, to provide both excellent clinical results and medical-device grade sterile allografts with minimal risk of disease transmission.

Publication types

  • Review

MeSH terms

  • Animals
  • Anterior Cruciate Ligament / surgery*
  • Biomechanical Phenomena / radiation effects
  • Dose-Response Relationship, Radiation
  • Gamma Rays*
  • Humans
  • Reconstructive Surgical Procedures / methods*
  • Sterilization / methods*
  • Tendons / radiation effects*
  • Tendons / transplantation*
  • Transplantation, Homologous