Emergence of four cases of KPC-2 and KPC-3-carrying Klebsiella pneumoniae introduced to Switzerland, 2009-10

Euro Surveill. 2011 Mar 17;16(11):19817. doi: 10.2807/ese.16.11.19817-en.

Abstract

We report four epidemiologically unrelated cases of KPC-carrying Klebsiella pneumoniae identified in Switzerland between May 2009 and November 2010. Three cases were transferred from Italy (two KPC-3, one KPC-2) and one from Greece (KPC-2). Resistance to colistin and doxycycline emerged in one KPC-3-carrying K. pneumoniae strain during therapy. These results demonstrate ongoing dissemination of KPC throughout Europe. Rapid and reliable identification of KPC and implementation of control measures is essential to limit spread.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Disease Outbreaks
  • Drug Resistance, Multiple, Bacterial / genetics
  • Female
  • Greece
  • Humans
  • Italy
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / genetics
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / classification*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Polymerase Chain Reaction
  • Species Specificity
  • Switzerland / epidemiology
  • Treatment Outcome
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Bacterial Proteins
  • beta-Lactamases
  • beta-lactamase KPC-2, Klebsiella pneumoniae
  • beta-lactamase KPC-3, Klebsiella pneumoniae