Abstract
The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based Aβ aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu(2+) and Zn(2+) and can target metal-Aβ40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism
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Chelating Agents / chemistry*
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Coordination Complexes / chemistry
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Coordination Complexes / toxicity
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Copper / chemistry
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Metals / chemistry*
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Molecular Conformation
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Peptide Fragments / chemistry*
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Peptide Fragments / metabolism
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Zinc / chemistry
Substances
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Amyloid beta-Peptides
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Chelating Agents
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Coordination Complexes
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Metals
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Peptide Fragments
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amyloid beta-protein (1-40)
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Copper
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Zinc