S-phase-coupled apoptosis in tumor suppression

Cell Mol Life Sci. 2011 Jun;68(11):1883-96. doi: 10.1007/s00018-011-0666-x. Epub 2011 Mar 25.


DNA replication is essential for accurate transmission of genomic information from parental to daughter cells. DNA replication is licensed once per cell division cycle. This process is highly regulated by both positive and negative regulators. Over-replication, under-replication, as well as DNA damage in a cell all induce the activation of checkpoint control pathways such as ATM/ATR, CHK kinases, and the tumor suppressor protein p53, which provide "damage controls" via either DNA repairs or apoptosis. This review focuses on accumulating evidence, with the emphasis on recently discovered Killin, that S-phase checkpoint control is crucial for a mammalian cell to make a life and death decision in order to safeguard genome integrity.

Publication types

  • Review

MeSH terms

  • Apoptosis*
  • E2F4 Transcription Factor / metabolism
  • Humans
  • S Phase*
  • Signal Transduction
  • Tumor Suppressor Proteins / metabolism


  • E2F4 Transcription Factor
  • KLLN protein, human
  • Tumor Suppressor Proteins