Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins

Acta Physiol (Oxf). 2012 Jan;204(1):8-16. doi: 10.1111/j.1748-1716.2011.02287.x. Epub 2011 Apr 22.


The Wnt family of signalling proteins has essential functions in development and adult tissue homoeostasis throughout the animal kingdom. Although signalling cascades triggered by Wnt proteins have been extensively studied, much remains to be learned about how Wnts are produced and secreted. Over the past few years, it has become clear that the secretion of Wnt proteins requires a specialized trafficking pathway. As this pathway has been discussed in two recent reviews (Lorenowicz & Korswagen 2009, Port & Basler 2010), we will focus our discussion on the key questions that need to be addressed to gain a more complete understanding of the mechanism and regulation of this essential secretion pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endosomes / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Lipids / chemistry
  • Protein Processing, Post-Translational
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway / physiology*


  • Intracellular Signaling Peptides and Proteins
  • Lipids
  • Wnt Proteins