Non-mitotic functions of the Anaphase-Promoting Complex

Semin Cell Dev Biol. 2011 Aug;22(6):572-8. doi: 10.1016/j.semcdb.2011.03.010. Epub 2011 Mar 23.


The Anaphase-Promoting Complex or Cyclosome (APC/C) is an E3 ubiquitin ligase whose activation requires the binding of a cofactor, either Cdc20 or Cdh1. While APC/C-Cdc20 is a major player during mitotic exit, APC/C-Cdh1 plays a central role in maintaining quiescence and controlling the onset of DNA replication. In addition, APC/C-Cdh1 is essential for endoreduplication, a process in which several rounds of DNA synthesis occur without mitosis. Recent data suggest that the APC/C is also involved in differentiation and metabolism, and plays important roles in postmitotic cells such as neurons. Thus, the APC/C is not only critical for anaphase onset but also regulates many other cellular processes during G1/S or in quiescent cells.

Publication types

  • Review

MeSH terms

  • Anaphase*
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Antigens, CD
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cdc20 Proteins
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cell Differentiation
  • DNA Replication
  • Gene Expression Regulation, Developmental
  • Genomic Instability
  • Humans
  • Mice
  • Neurons / physiology*
  • Protein Binding
  • Spindle Apparatus / genetics
  • Spindle Apparatus / metabolism*
  • Ubiquitin-Protein Ligase Complexes / genetics
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*


  • Antigens, CD
  • CDH1 protein, human
  • Cadherins
  • Cdc20 Proteins
  • Cell Cycle Proteins
  • CDC20 protein, human
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Ubiquitin-Protein Ligases