The immunopathophysiology of multiple sclerosis

Neurol Clin. 2011 May;29(2):257-78. doi: 10.1016/j.ncl.2010.12.009.


This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory damage of the central nervous system, B-cell involvement, and inflammatory damage of axons and neurons. This article preferentially focuses on MS rather than animal models of the disease, such as experimental autoimmune encephalomyelitis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / pathology
  • Axons / pathology
  • Brain / pathology
  • Cytokines / metabolism
  • Humans
  • Leukocytes / physiology
  • Lymphocytes / physiology
  • Models, Biological
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / metabolism
  • Multiple Sclerosis / pathology*
  • Neurons / pathology


  • Cytokines