On the 'rate of aging' in heterogeneous populations

Math Biosci. 2011 Jul;232(1):20-3. doi: 10.1016/j.mbs.2011.03.012. Epub 2011 Apr 1.

Abstract

It is well known that the rate of aging is constant for populations described by the Gompertz law of mortality. However, this is true only when a population is homogeneous. In this note, we consider the multiplicative frailty model with the baseline distribution that follows the Gompertz law and study the impact of heterogeneity on the rate of aging in this population. We show that the rate of aging in this case is a function of age and that it increases in (calendar) time when the baseline mortality rate decreases.

MeSH terms

  • Aging*
  • Models, Biological*
  • Proportional Hazards Models*