In utero exposure to bisphenol-A and its effect on birth weight of offspring

Reprod Toxicol. 2011 Jul;32(1):64-8. doi: 10.1016/j.reprotox.2011.03.002. Epub 2011 Mar 31.


To examine the effect of in utero BPA exposure on the birth weight of offspring, a total of 587 children from families in which parent(s) did or did not have occupational exposure to BPA were examined. Their birth weights were obtained by an in-person interview of the mother. Parental BPA exposure level during the index pregnancy was determined through personal air sampling measurements and exposure history. After controlling for potential confounders, parental exposure to BPA in the workplace during pregnancy was associated with decreased birth weight. The association was stronger for maternal exposure which is statistically significant (P=0.02). A dose-response relationship was observed with increased BPA exposure levels in pregnancy associated with greater magnitude of decrease of birth weight in offspring (P=0.003). Our findings provide the new epidemiologic evidence suggesting that in utero exposure to BPA during pregnancy may be associated with decreased birth weight in offspring.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Air Pollutants, Occupational / toxicity*
  • Benzhydryl Compounds
  • Birth Weight / drug effects
  • Environmental Monitoring
  • Epidemiological Monitoring
  • Female
  • Fetal Growth Retardation / chemically induced*
  • Fetal Growth Retardation / epidemiology
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Male
  • Maternal Exposure / adverse effects*
  • Paternal Exposure / adverse effects*
  • Phenols / toxicity*
  • Pregnancy


  • Air Pollutants, Occupational
  • Benzhydryl Compounds
  • Phenols
  • bisphenol A