Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for early acute kidney injury

Crit Care Clin. 2011 Apr;27(2):379-89. doi: 10.1016/j.ccc.2010.12.003.


Based on information to date, although limitations in the accuracy of NGAL in predicting AKI persist, the preponderance of published studies demonstrate that NGAL, when measured in the plasma and in the urine, is a reliable biomarker for the subsequent development of clinically apparent AKI. If very early detection of AKI, via the measurement of plasma or urinary NGAL, can be followed by effective treatment to abort the development or limit the severity of AKI, and therefore decrease the rate of RRT, length of hospitalization stay, and/or mortality risk, NGAL measurement will become a critically important diagnostic tool in critical care medicine, pediatrics, and surgery.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / therapy
  • Acute Kidney Injury / urine*
  • Acute-Phase Proteins / urine*
  • Biomarkers / blood
  • Biomarkers / urine
  • Humans
  • Lipocalin-2
  • Lipocalins / blood
  • Lipocalins / urine*
  • Predictive Value of Tests
  • Prognosis
  • Proto-Oncogene Proteins / blood
  • Proto-Oncogene Proteins / urine*
  • ROC Curve


  • Acute-Phase Proteins
  • Biomarkers
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Proto-Oncogene Proteins