Comparison of inhaled terbutaline and inhaled terbutaline plus ipratropium bromide in acute asthmatic children

Asian Pac J Allergy Immunol. 1990 Jun;8(1):45-8.

Abstract

Twenty asthmatic children, aged 4 to 15 years, consisting of 14 boys and 6 girls, were studied during acute episodes of asthmatic attacks. A group of 10 children each received either inhaled terbutaline 0.5 mg or inhaled terbutaline 0.5 mg followed by ipratropium bromide 0.04 mg 15 minutes later through a 750-ml volumetric spacer. Significant increases in FEV1 over the baseline were observed from 2 minutes to 2 hours and from 2 minutes to 6 hours following the first and second regimen respectively. A slightly greater increase and longer duration in FEV1 were observed in the combined drug treatment and very slight decreases in systolic and diastolic blood pressure below the base-line were observed. Neither regimen showed any serious adverse effect on the heart rate and respiratory rate.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Adolescent
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Atropine Derivatives / therapeutic use*
  • Blood Pressure / drug effects
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Female
  • Forced Expiratory Volume / drug effects
  • Heart Rate / drug effects
  • Humans
  • Ipratropium / administration & dosage
  • Ipratropium / therapeutic use*
  • Male
  • Nebulizers and Vaporizers
  • Respiration / drug effects
  • Terbutaline / administration & dosage
  • Terbutaline / therapeutic use*

Substances

  • Atropine Derivatives
  • Ipratropium
  • Terbutaline