doi: 10.1016/s1734-1140(11)70411-x.
Endocannabinoid System Protects Against Cryptogenic Seizures
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- PMID: 21441624
- DOI: 10.1016/s1734-1140(11)70411-x
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Endocannabinoid System Protects Against Cryptogenic Seizures
Pharmacol Rep.
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Free article
Abstract
Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.
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