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. 2011;63(1):165-8.
doi: 10.1016/s1734-1140(11)70411-x.

Endocannabinoid System Protects Against Cryptogenic Seizures

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Endocannabinoid System Protects Against Cryptogenic Seizures

Clementina M van Rijn et al. Pharmacol Rep. .
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Abstract

Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.

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