Endocannabinoid system protects against cryptogenic seizures

Pharmacol Rep. 2011;63(1):165-8. doi: 10.1016/s1734-1140(11)70411-x.

Abstract

Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.

MeSH terms

  • Administration, Oral
  • Animals
  • Brain / drug effects
  • Brain / pathology
  • Cannabinoid Receptor Modulators / metabolism*
  • Disease Models, Animal
  • Drug Administration Schedule
  • Electroencephalography
  • Endocannabinoids*
  • Female
  • Piperidines / administration & dosage
  • Piperidines / toxicity*
  • Pyrazoles / administration & dosage
  • Pyrazoles / toxicity*
  • Rats
  • Rats, Wistar
  • Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
  • Rimonabant
  • Seizures / chemically induced*
  • Time Factors

Substances

  • Cannabinoid Receptor Modulators
  • Endocannabinoids
  • Piperidines
  • Pyrazoles
  • Receptor, Cannabinoid, CB1
  • Rimonabant