Abstract
Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.
MeSH terms
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Administration, Oral
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Animals
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Brain / drug effects
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Brain / pathology
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Cannabinoid Receptor Modulators / metabolism*
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Disease Models, Animal
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Drug Administration Schedule
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Electroencephalography
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Endocannabinoids*
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Female
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Piperidines / administration & dosage
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Piperidines / toxicity*
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Pyrazoles / administration & dosage
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Pyrazoles / toxicity*
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Rats
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Rats, Wistar
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Receptor, Cannabinoid, CB1 / antagonists & inhibitors*
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Rimonabant
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Seizures / chemically induced*
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Time Factors
Substances
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Piperidines
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Pyrazoles
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Receptor, Cannabinoid, CB1
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Rimonabant