Olive oil and haemostasis: platelet function, thrombogenesis and fibrinolysis

Curr Pharm Des. 2011;17(8):778-85. doi: 10.2174/138161211795428876.


Mediterranean diet is one of the healthiest nutritional models used in developed countries. The actual interest in this dietary model is based in two main premises. First, the high palatability for the consumer, which aids to the adherence to the model on a life-long basis, and second, the mounting evidence on the beneficial properties that its consumption provokes in cardiovascular risk factors, cancer and cognitive age associated decline. Olive oil is the principal component of Mediterranean diet, both by its predominant position as the main energy source, and its presence in almost all cooked and/or seasoned food. The influence of the olive oil on the beneficial effects of the Mediterranean diet is well known. Albeit an initial stage in which monounsaturated fatty acids (mainly oleic acid) were studied as the sole player of these effects, the knowledge about the micronutrients has evolved to a much more complex model in which the processing of the oil and the content in some minor contents of the virgin olive oil play a fundamental role. In this article we will review the current evidences that relate olive oil with the haemostatic system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticoagulants / pharmacology*
  • Dietary Fats / pharmacology
  • Factor VII / metabolism
  • Fatty Acids, Monounsaturated / pharmacology
  • Fibrinogen / metabolism
  • Fibrinolysis / drug effects*
  • Hemostasis / drug effects*
  • Humans
  • Olive Oil
  • Phenols / pharmacology
  • Plant Oils / pharmacology*
  • Plasminogen Activator Inhibitor 1 / blood
  • Platelet Activation / drug effects*
  • Thromboplastin / metabolism
  • Thrombosis / metabolism*
  • Thromboxanes / blood
  • von Willebrand Factor / metabolism


  • Anticoagulants
  • Dietary Fats
  • Fatty Acids, Monounsaturated
  • Olive Oil
  • Phenols
  • Plant Oils
  • Plasminogen Activator Inhibitor 1
  • SERPINE1 protein, human
  • Thromboxanes
  • von Willebrand Factor
  • Factor VII
  • Fibrinogen
  • Thromboplastin