Trisomy 21 in transient myeloproliferative disorder

Cancer Genet Cytogenet. 1990 Sep;48(2):259-64. doi: 10.1016/0165-4608(90)90129-x.


Transient leukemia in phenotypically normal children is rare. A newborn child in whom fever and tachypnea developed at age 2 days had a white blood cell count of 20.1 x 10(9)/L and many abnormal blast cells. Chromosome analysis of spontaneously dividing cells from the blood showed these to have trisomy 21, and 80% of cells in the marrow were also trisomic. No trisomic cells were present in skin fibroblast cultures. At age 6 months, at which time the blood film appeared normal, trisomic cells were no longer present.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Cells, Cultured
  • Down Syndrome / genetics*
  • Female
  • Humans
  • Infant, Newborn
  • Myeloproliferative Disorders / genetics*