Abstract
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
MeSH terms
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DNA (Cytosine-5-)-Methyltransferases / genetics*
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DNA Methylation
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DNA Methyltransferase 3A
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Epigenesis, Genetic
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Hematopoiesis / genetics
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Humans
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Leukemia, Myeloid, Acute / enzymology*
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Leukemia, Myeloid, Acute / genetics*
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Models, Genetic
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Mutation*
Substances
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DNMT3A protein, human
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DNA (Cytosine-5-)-Methyltransferases
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DNA Methyltransferase 3A