Total synthesis and complete structural assignment of thiocillin I

J Am Chem Soc. 2011 Apr 20;133(15):5900-4. doi: 10.1021/ja110166x. Epub 2011 Mar 29.

Abstract

The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry

Substances

  • Anti-Bacterial Agents
  • Peptides
  • thiocillin