High b-value q-space analyzed diffusion-weighted MRI using 1.5 tesla clinical scanner; determination of displacement parameters in the brains of normal versus multiple sclerosis and low-grade glioma subjects

J Neuroimaging. 2012 Jul;22(3):279-84. doi: 10.1111/j.1552-6569.2011.00596.x. Epub 2011 Mar 29.

Abstract

Purpose: We aimed to determine the displacement parameters in the brains of normal individuals relative to brain parenchymal abnormalities, such as multiple sclerosis (MS) and low-grade glioma, by q-space imaging (QSI) using 1.5-T magnetic resonance (MR) scanner.

Materials and methods: Thirty-five normal, three pathologically proven low-grade glioma, and five MS subjects were imaged by a 1.5-T MR unit for QSI (b-values, 0-12,000 s/mm(2)). Mean displacement (MD) values in white matter (WM), gray matter (GM), and lateral ventricle (cerebrospinal fluid [CSF]) of normal subjects, plaques, and normal appearing WM (NAWM) of MS subjects and glioma lesions were calculated. Mann-Whitney U test was used for comparison.

Results: In normal subjects, MD values were 6.6 ± 0.2, 8.44 ± 0.41, and 17.08 ± 0.80 μm for WM, GM, and CSF, respectively, while those for NAWM and WM plaques in MS, and glioma lesions were significantly higher at 7.0 ± 0.17, 9.3 ± 2.3, and 9.6 ± 0.40 μm, respectively, compared to WM in normal subjects.

Conclusion: We propose that the relative values of MD obtained by QSI in control and diseased tissues can be useful for diagnosing various WM abnormalities.

MeSH terms

  • Adolescent
  • Adult
  • Brain / pathology*
  • Brain Neoplasms / pathology*
  • Diffusion Magnetic Resonance Imaging / methods*
  • Female
  • Glioma / pathology*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Male
  • Middle Aged
  • Multiple Sclerosis / pathology*
  • Nerve Fibers, Myelinated / pathology*
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Young Adult