Sulphilimine cross-links in Goodpasture's disease

Clin Exp Immunol. 2011 May;164 Suppl 1(Suppl 1):4-6. doi: 10.1111/j.1365-2249.2011.04356.x.


The sulphilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anti-Glomerular Basement Membrane Disease / immunology*
  • Autoantigens / chemistry*
  • Autoantigens / immunology*
  • Collagen Type IV / chemistry*
  • Collagen Type IV / immunology*
  • Cross-Linking Reagents / chemistry
  • Epitopes, B-Lymphocyte / chemistry
  • Epitopes, B-Lymphocyte / immunology
  • Epitopes, T-Lymphocyte / chemistry
  • Epitopes, T-Lymphocyte / immunology
  • Humans
  • Protein Conformation


  • Autoantigens
  • Collagen Type IV
  • Cross-Linking Reagents
  • Epitopes, B-Lymphocyte
  • Epitopes, T-Lymphocyte
  • type IV collagen alpha3 chain