Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy

Pharmacogenomics. 2011 Mar;12(3):319-25. doi: 10.2217/pgs.10.183.

Abstract

Aim: To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs.

Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped in a total of 590 Han Chinese epilepsy patients (262 drug resistant and 328 drug responsive). Genotype and allele distributions in drug-responsive and drug-resistant patients were compared.

Results: Genotype distributions of all the selected SNPs were consistent with Hardy-Weinberg equilibrium. None of the polymorphisms, either genotype or allele distributions, were significantly associated with drug resistance. For each gene, no haplotypes of over 1% frequency, and that included all SNPs of the gene, were associated with drug resistance.

Conclusion: This gene-wide tagging study revealed no association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters / genetics*
  • Adolescent
  • Adult
  • Alleles
  • Asian Continental Ancestry Group
  • Drug Resistance, Multiple / genetics*
  • Epilepsy / drug therapy*
  • Epilepsy / genetics*
  • Female
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Multidrug Resistance-Associated Proteins / genetics*
  • Neoplasm Proteins / genetics*
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide / genetics
  • Young Adult

Substances

  • ABCC5 protein, human
  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters
  • Multidrug Resistance-Associated Proteins
  • Neoplasm Proteins
  • multidrug resistance-associated protein 2