Uncommon Neosartorya udagawae fungus as a causative agent of severe corneal infection

J Clin Microbiol. 2011 Jun;49(6):2357-60. doi: 10.1128/JCM.00134-11. Epub 2011 Mar 30.

Abstract

We report the first documented case of a posttraumatic fungal keratitis caused by Neosartorya udagawae. The patient was empirically treated with fluconazole until a corneal scraping grew an Aspergillus fumigatus-like fungus, and itraconazole therapy was then established. A sequence-based approach assigned the isolate to the species. Five months after completion of antifungal therapy, endophthalmitis occurred and orbital exenteration was necessary.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / administration & dosage
  • Corneal Diseases / drug therapy
  • Corneal Diseases / microbiology*
  • Corneal Diseases / pathology*
  • Corneal Diseases / surgery
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Debridement
  • Fluconazole / administration & dosage
  • Humans
  • Itraconazole / administration & dosage
  • Male
  • Microbial Sensitivity Tests
  • Microscopy
  • Mycoses / diagnosis*
  • Mycoses / drug therapy
  • Mycoses / pathology*
  • Mycoses / surgery
  • Neosartorya / isolation & purification*
  • Phylogeny
  • Sequence Analysis, DNA
  • Wounds and Injuries / complications*

Substances

  • Antifungal Agents
  • DNA, Fungal
  • DNA, Ribosomal
  • DNA, Ribosomal Spacer
  • Itraconazole
  • Fluconazole