Final adult height in children with congenital adrenal hyperplasia treated with growth hormone

J Clin Endocrinol Metab. 2011 Jun;96(6):1710-7. doi: 10.1210/jc.2010-2699. Epub 2011 Mar 30.


Context: Patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency typically reach a final adult height well below their mid-parental target height.

Objective: The objective of this study was to examine whether GH alone or in combination with an LHRH analog (LHRHa) improved the final adult height in patients with CAH.

Design: The study was a nonrandomized prospective study.

Setting: The study was conducted at two university hospitals in New York City, NY.

Participants: Thirty-four patients with CAH treated with GH participated in this study. Nineteen males and 15 females who were predicted to be more than 2 SD below their mid-parental target height or more than 2 SD below the population mean received GH until reaching final adult height. In addition to GH, 27 patients (16 males, 11 females) were also treated with an LHRHa.

Intervention: The mean duration of GH treatment was 5.6 ± 1.8 yr in males and 4.5 ± 1.6 yr in females. The mean duration of LHRHa therapy was 3.7 ± 1.7 yr for both sexes.

Main outcome measures: The primary endpoint variables were final adult height, final height discrepancy, and gain in height.

Results: Males reached a significantly higher final adult height (172.0 ± 4.8 cm) than their initial predicted height (162.8 ± 7.7 cm) (P < 0.00001). Females also reached a significantly higher final adult height (162.2 ± 5.3 cm) than initially predicted (151.7 ± 5.2 cm) (P < 0.0000001). Mean gain in height was 9.2 ± 6.7 cm in males and 10.5 ± 3.7 cm in females.

Conclusion: Our results indicate that GH alone or in combination with LHRHa improves final adult height in patients with CAH.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenal Hyperplasia, Congenital / physiopathology*
  • Adrenal Hyperplasia, Congenital / therapy*
  • Adult
  • Body Height / physiology*
  • Child
  • Female
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Human Growth Hormone / therapeutic use*
  • Humans
  • Male
  • Patient Selection
  • Prospective Studies
  • Treatment Outcome


  • Human Growth Hormone
  • Gonadotropin-Releasing Hormone