Quantitative multi-compartmental SPECT image analysis for lateralization of temporal lobe epilepsy

Epilepsy Res. 2011 Jun;95(1-2):35-50. doi: 10.1016/j.eplepsyres.2011.02.011. Epub 2011 Mar 30.


This study assesses the utility of compartmental analysis of SPECT data in lateralizing ictal onset in cases of a putative mesial temporal lobe epilepsy (mTLE). An institutional archival review provided 46 patients (18M, 28F) operated for a putative mTLE who achieved an Engel class Ia postoperative outcome. This established the standard to assure a true ictal origin. Ictal and interictal SPECT images were separately coregistered to T1-weighted (T1W) magnetic resonance (MR) image using a rigid transformation and the intensities matched with an l(1) norm minimization technique. The T1W MR image was segmented into separate structures using an atlas-based automatic segmentation technique with the hippocampi manually segmented to improve accuracy. Mean ictal-interictal intensity difference values were calculated for select subcortical structures and the accuracy of lateralization evaluated using a linear classifier. Hippocampal SPECT analysis yielded the highest lateralization accuracy (91%) followed by the amygdala (87%), putamen (67%) and thalamus (61%). Comparative FLAIR and volumetric analyses yielded 89% and 78% accuracies, respectively. A multi-modality analysis did not generate a higher accuracy (89%). A quantitative anatomically compartmented approach to SPECT analysis yields a particularly high lateralization accuracy in the case of mTLE comparable to that of quantitative FLAIR MR imaging. Hippocampal segmentation in this regard correlates well with ictal origin and shows good reliability in the preoperative analysis.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Cysteine / analogs & derivatives
  • Dominance, Cerebral
  • Epilepsy, Post-Traumatic / diagnostic imaging
  • Epilepsy, Post-Traumatic / pathology
  • Epilepsy, Temporal Lobe / diagnostic imaging*
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / surgery
  • Female
  • Head Injuries, Closed / complications
  • Hippocampus / diagnostic imaging
  • Hippocampus / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Organotechnetium Compounds
  • Preoperative Care
  • Radiopharmaceuticals
  • Retrospective Studies
  • Technetium Tc 99m Exametazime
  • Temporal Lobe / diagnostic imaging*
  • Temporal Lobe / pathology
  • Tomography, Emission-Computed, Single-Photon / methods*
  • Young Adult


  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Technetium Tc 99m Exametazime
  • technetium Tc 99m bicisate
  • Cysteine