In Vivo Antinociceptive and Anti-Inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil

Med Princ Pract. 2011;20(3):231-6. doi: 10.1159/000323756. Epub 2011 Mar 29.

Abstract

Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by the Malaysian Agriculture Research and Development Institute (MARDI) using various in vivo models.

Materials and methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivo model systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg).

Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation.

Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen / physiology
  • Analgesics / pharmacology*
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Coconut Oil
  • Disease Models, Animal
  • Edema / chemically induced
  • Edema / prevention & control
  • Granuloma / prevention & control
  • Malaysia
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Muscle Contraction / drug effects
  • Pain / drug therapy*
  • Pain Measurement / methods
  • Phytotherapy / methods*
  • Plant Oils / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Oils
  • Coconut Oil