A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution

Med Sci Monit. 2011 Apr;17(4):HY1-4. doi: 10.12659/msm.881698.


Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).<br />

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Aerosols / administration & dosage*
  • Humans
  • Hydrogen / administration & dosage*
  • Models, Biological
  • Radiation Pneumonitis / prevention & control*
  • Radiation Pneumonitis / radiotherapy*
  • Solutions


  • Aerosols
  • Solutions
  • Hydrogen