Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?

Nina A Daha; Rene E M Toes

doi:10.1038/nrrheum.2011.28

Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?

Nat Rev Rheumatol. 2011 Apr;7(4):202-3. doi: 10.1038/nrrheum.2011.28.

Authors

Nina A Daha¹, Rene E M Toes

Affiliation

¹ Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, The Netherlands. n.a.daha@lumc.nl

PMID: 21455249
DOI: 10.1038/nrrheum.2011.28

Abstract

Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.

Publication types

News
Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid / classification
Arthritis, Rheumatoid / genetics*
Arthritis, Rheumatoid / immunology
Autoantibodies / genetics*
Genetic Association Studies
Genetic Predisposition to Disease*
Genetic Variation
Humans
Peptides, Cyclic / immunology*
Treatment Outcome

Substances

Autoantibodies
Peptides, Cyclic
cyclic citrullinated peptide