Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?

Nat Rev Rheumatol. 2011 Apr;7(4):202-3. doi: 10.1038/nrrheum.2011.28.


Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.

Publication types

  • News
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / classification
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology
  • Autoantibodies / genetics*
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genetic Variation
  • Humans
  • Peptides, Cyclic / immunology*
  • Treatment Outcome


  • Autoantibodies
  • Peptides, Cyclic
  • cyclic citrullinated peptide