Left ventricular mass regression after aortic valve replacement measured by ultrafast computed tomography

Am Heart J. 1990 Oct;120(4):919-27. doi: 10.1016/0002-8703(90)90211-f.


Left ventricular mass and function were measured using ultrafast computed tomography, and were correlated with clinical status in 17 patients with aortic stenosis and/or insufficiency undergoing aortic valve replacement or balloon valvuloplasty. Wall mass was 159 +/- 38 gm/m2 initially, decreased 25% to 116 +/- 29 gm/m2 at 4 month (p less than 0.001), and decreased a total of 34% to 105 +/- 33 gm/m2 at 8 months after valve repair. By 8 months not only was the mean wall mass within the normal range, but only three patients retained abnormal hypertrophy. Ejection fraction increased 8% (p = 0.06). Clinical function improved in all patients, with only three patients remaining outside of New York Heart Association functional class 1 at 8 months. Regression of ventricular mass into the normal range correlated with attainment of class 1 functional status (p less than 0.02), despite a lack of increase of ejection fraction. The single patient followed for 8 months after valvuloplasty had minor wall mass regression and minor clinical improvement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aortic Valve Insufficiency / surgery*
  • Aortic Valve Insufficiency / therapy
  • Aortic Valve Stenosis / surgery*
  • Aortic Valve Stenosis / therapy
  • Cardiomegaly / diagnostic imaging*
  • Cardiomegaly / physiopathology
  • Catheterization
  • Follow-Up Studies
  • Heart Valve Prosthesis*
  • Humans
  • Tomography, X-Ray Computed / methods*
  • Ventricular Function, Left / physiology*