High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype

Genome Biol. 2011;12(3):219. doi: 10.1186/gb-2011-12-3-219. Epub 2011 Mar 28.

Abstract

High-throughput phenotyping approaches (phenomics) are being combined with genome-wide genetic screens to identify alterations in phenotype that result from gene inactivation. Here we highlight promising technologies for 'phenome-scale' analyses in multicellular organisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Automation, Laboratory
  • Biotechnology
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / metabolism
  • Genetic Association Studies / methods*
  • High-Throughput Screening Assays / methods*
  • Mice
  • Phenotype*
  • Plants / genetics
  • Plants / metabolism
  • RNA Interference