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Randomized Controlled Trial
. 2011 Apr 1;11:83.
doi: 10.1186/1471-2334-11-83.

A Longitudinal Study of Allergy and Intestinal Helminth Infections in Semi Urban and Rural Areas of Flores, Indonesia (ImmunoSPIN Study)

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Free PMC article
Randomized Controlled Trial

A Longitudinal Study of Allergy and Intestinal Helminth Infections in Semi Urban and Rural Areas of Flores, Indonesia (ImmunoSPIN Study)

Firdaus Hamid et al. BMC Infect Dis. .
Free PMC article

Abstract

Background: The prevalence of asthma and atopic disease has been reported to be low in low income countries, however helminth infections are likely to be high among these communities. The question of whether helminth infections play a role in allergic diseases can best be addressed by intervention studies. None of the studies so far have been based on a large scale placebo-controlled trial.

Method/design: This study was designed to assess how intestinal helminth infections can influence the immune response and atopic and allergic disorders in children in Indonesia. The relations between allergic outcomes and infection and lifestyle factors will be addressed. This study was set up among school-age children in semi urban and rural areas, located in Ende District of Flores Island, Indonesia. A randomized placebo-controlled anthelmintic treatment trial to elucidate the impact of helminth infections on the prevalence of skin prick test (SPT) reactivity and symptoms of allergic diseases will be performed. The children living in these semi-urban and rural areas will be assessed for SPT to allergens before and after 1 and 2 years of treatment as the primary outcome of the study; the secondary outcome is symptoms (asthma and atopic dermatitis); while the tertiary outcome is immune responses (both antibody levels to allergens and cellular immune responses).

Discussion: The study will provide information on the influence of helminth infections and anthelmintic treatment on immune response, atopy and allergic disorders.

Trial registration: Current Controlled Trials ISRCTN: ISRCTN83830814.

Figures

Figure 1
Figure 1
The map of the study area in Flores, Indonesia. A. Indonesia map. B. Study areas in Flores island which star sign. C. Nangapanda (semi urban area) where each dot represents one household. D. Anaranda (rural area) where each dot represents one household.
Figure 2
Figure 2
Profile of the ImmunoSPIN-allergy sub project http://www.immunospin.org in study areas, Flores, Indonesia.
Figure 3
Figure 3
Conceptual of principal question study.
Figure 4
Figure 4
Distribution of sex and age in school children participating in the study. Distribution of children participants in the semi urban (Nangapanda) and the rural (Anaranda) areas.

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