Abstract
Progress has been made in deciphering the mechanisms on Orientia tsutsugamushi-host interaction. The genome sequencing, microarray and proteomic analyses of this ancient bacterium have provided a wealth of new information. This paper reviews the general characteristics of O. tsutsugamushi and recent developments especially in signaling events involved in the bacteria--host interaction.
Copyright © 2011 Institut Pasteur. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis
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Bacterial Adhesion
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Bacterial Secretion Systems / genetics
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Cytokines / metabolism
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Genome, Bacterial
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Host-Pathogen Interactions / genetics
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Host-Pathogen Interactions / immunology*
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Humans
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Microarray Analysis / methods
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Orientia tsutsugamushi / genetics*
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Orientia tsutsugamushi / pathogenicity*
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Proteomics / methods
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Scrub Typhus / genetics*
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Scrub Typhus / immunology
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Sequence Analysis
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Signal Transduction*
Substances
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Bacterial Secretion Systems
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Cytokines