doi: 10.1016/j.cell.2011.03.020.
Genetic interactions in cancer progression and treatment
Affiliations
- PMID: 21458666
- DOI: 10.1016/j.cell.2011.03.020
Item in Clipboard
Genetic interactions in cancer progression and treatment
Cell.
.
Free article
Abstract
As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
-
Identifying Epistasis in Cancer Genomes: A Delicate Affair.Cell. 2019 May 30;177(6):1375-1383. doi: 10.1016/j.cell.2019.05.005. Cell. 2019. PMID: 31150618 Free PMC article. Review.
-
Simulating Evolution in Asexual Populations with Epistasis.Methods Mol Biol. 2021;2212:121-154. doi: 10.1007/978-1-0716-0947-7_9. Methods Mol Biol. 2021. PMID: 33733354
-
Epistatic interactions and drug response.J Pathol. 2014 Jan;232(2):255-63. doi: 10.1002/path.4265. J Pathol. 2014. PMID: 24105606 Review.
-
Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types.Mol Syst Biol. 2015 Jul 30;11(7):824. doi: 10.15252/msb.20156102. Mol Syst Biol. 2015. PMID: 26227665 Free PMC article.
-
Mapping the protein-protein and genetic interactions of cancer to guide precision medicine.Curr Opin Genet Dev. 2019 Feb;54:110-117. doi: 10.1016/j.gde.2019.04.005. Epub 2019 Jul 6. Curr Opin Genet Dev. 2019. PMID: 31288129 Free PMC article. Review.
Cited by
-
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Cancer Discov. 2012 Feb;2(2):172-189. doi: 10.1158/2159-8290.CD-11-0224. Epub 2011 Dec 29. Cancer Discov. 2012. PMID: 22585861 Free PMC article.
-
Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus.Oncogene. 2014 Jan 16;33(3):347-57. doi: 10.1038/onc.2012.586. Epub 2013 Jan 14. Oncogene. 2014. PMID: 23318448 Free PMC article.
-
A map of directional genetic interactions in a metazoan cell.Elife. 2015 Mar 6;4:e05464. doi: 10.7554/eLife.05464. Elife. 2015. PMID: 25748138 Free PMC article.
-
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor.Mol Syst Biol. 2021 Mar;17(3):e9526. doi: 10.15252/msb.20209526. Mol Syst Biol. 2021. PMID: 33750001 Free PMC article.
-
Recurrent WWTR1 S89W mutations and Hippo pathway deregulation in clear cell carcinomas of the cervix.J Pathol. 2022 Aug;257(5):635-649. doi: 10.1002/path.5910. Epub 2022 May 20. J Pathol. 2022. PMID: 35411948 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
