Genetic interactions in cancer progression and treatment

Cell. 2011 Apr 1;145(1):30-8. doi: 10.1016/j.cell.2011.03.020.


As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Progression
  • Epistasis, Genetic*
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / physiopathology