Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study

Fertil Steril. 2011 Jun 30;95(8):2574-7. doi: 10.1016/j.fertnstert.2011.02.047. Epub 2011 Apr 2.

Abstract

Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Effect
  • Cohort Studies
  • Diethylstilbestrol / adverse effects*
  • Endocrine Disruptors / adverse effects*
  • Estrogens, Non-Steroidal / adverse effects*
  • Female
  • France
  • Humans
  • Hypospadias / chemically induced
  • Hypospadias / epidemiology*
  • Hypospadias / genetics
  • Male
  • Maternal Exposure*
  • Pedigree
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Sex Factors

Substances

  • Endocrine Disruptors
  • Estrogens, Non-Steroidal
  • Diethylstilbestrol