The effects of desflurane and sevoflurane on the peri- and postoperative bleeding of adenotonsillectomy patients

Int J Pediatr Otorhinolaryngol. 2011 Jun;75(6):790-2. doi: 10.1016/j.ijporl.2011.03.008. Epub 2011 Apr 1.


Objective: To compare the effects of, volatile anesthetics, desflurane and sevoflurane on intra-operative and postoperative bleeding in patients who underwent tonsillectomy and adenoidectomy.

Material and method: Totally 40 children (14 girl and 26 boys) aged between 2 and 16years were included in this prospective randomized double-blind clinical trial. The patients underwent conventional cold tonsillectomy and curettage adenoidectomy under general anesthesia. For the maintenance of anesthesia, the patients were randomized into two groups; desflurane group and sevoflurane group, each including 20 subjects. Desflurane concentration was set between 4% and 6% (0.7-0.9 MAC), whereas sevoflurane concentration was set between 2% and 2.5% (0.7-0.9 MAC). The amount of perioperative bleeding in milliliters was measured by using separate aspirator bags for each patient.

Results: Desflurane caused significantly lower amount of perioperative bleeding compared to sevoflurane (p=0.03). No significant difference was observed between the two groups in terms of age, body mass index and operation duration, respectively (p=0.20, p=0.49, p=0.07).

Conclusion: Desflurane, which is one of the volatile anesthetics, leads to a lower amount of intraoperative bleeding than sevoflurane during tonsillectomy and adenoidectomy operations.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adenoidectomy / adverse effects*
  • Adolescent
  • Anesthetics, Inhalation
  • Blood Loss, Surgical / prevention & control*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Desflurane
  • Double-Blind Method
  • Female
  • Humans
  • Isoflurane / analogs & derivatives*
  • Isoflurane / therapeutic use
  • Male
  • Methyl Ethers / therapeutic use*
  • Postoperative Hemorrhage / etiology
  • Postoperative Hemorrhage / prevention & control*
  • Sevoflurane
  • Tonsillectomy / adverse effects*
  • Treatment Outcome


  • Anesthetics, Inhalation
  • Methyl Ethers
  • Sevoflurane
  • Desflurane
  • Isoflurane