Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: better than we thought

Clin Infect Dis. 2011 Apr 15;52(8):1024-8. doi: 10.1093/cid/cir080.


We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immunosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bacteriological Techniques / methods*
  • Enzyme-Linked Immunosorbent Assay / methods
  • Female
  • Humans
  • Male
  • Melioidosis / diagnosis*
  • Middle Aged
  • ROC Curve
  • Sensitivity and Specificity