Lysosome positioning coordinates mTORC1 activity and autophagy

Nat Cell Biol. 2011 Apr;13(4):342-4. doi: 10.1038/ncb0411-342.

Abstract

Under nutrient-rich conditions, the nutrient-sensitive kinase mTOR (mammalian target of rapamycin) is recruited to the surface of lysosomes where it becomes activated and can promote cell growth and inhibit autophagy. In contrast, mTOR is inhibited in nutrient-poor conditions, leading to the induction of autophagy. The intracellular positioning of lysosomes in response to nutrient availability is now shown to orchestrate mTOR activation and regulate autophagy.

Publication types

  • News
  • Comment

MeSH terms

  • Autophagy / physiology*
  • Humans
  • Lysosomes / metabolism*
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes
  • Proteins / metabolism*
  • TOR Serine-Threonine Kinases

Substances

  • Multiprotein Complexes
  • Proteins
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1