Cancer: Lynch syndrome--how should colorectal cancer be managed?

Nat Rev Gastroenterol Hepatol. 2011 Apr;8(4):184-6. doi: 10.1038/nrgastro.2011.34.


An international consortium (the Colon Cancer Family Registry) has recently published interesting data on the risk of developing metachronous colorectal cancer (CRC) after treatment of primary CRC in patients with Lynch syndrome. The findings are clinically important as they might justify more extensive surgery to treat primary CRC in these patients.

MeSH terms

  • Colectomy
  • Colorectal Neoplasms / etiology*
  • Colorectal Neoplasms / surgery*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / complications*
  • Humans
  • Neoplasms, Second Primary / epidemiology*
  • Neoplasms, Second Primary / prevention & control
  • Quality of Life
  • Risk Factors
  • Treatment Outcome