Impaired left-ventricular cardiac function in male GPR30-deficient mice

Mol Med Rep. Jan-Feb 2011;4(1):37-40. doi: 10.3892/mmr.2010.402. Epub 2010 Nov 30.

Abstract

G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventricles from male mutant mice were enlarged. There were no malformations in the valves or outflow tract of the heart. Both the contractility and relaxation capacity of the left ventricle were reduced, leading to increased left‑ventricular end-diastolic pressure in GPR30-deficient mice. In conclusion, our data support a role for GPR30 in the gender-specific aspects of heart failure.

MeSH terms

  • Animals
  • Female
  • Gene Deletion*
  • Heart Failure / genetics
  • Heart Ventricles / pathology
  • Heart Ventricles / physiopathology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Receptors, Estrogen
  • Receptors, G-Protein-Coupled / genetics*
  • Sex Factors
  • Ventricular Function, Left*

Substances

  • GPER1 protein, mouse
  • Receptors, Estrogen
  • Receptors, G-Protein-Coupled