Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study

Gynecol Endocrinol. 2011 Nov;27(11):857-61. doi: 10.3109/09513590.2011.564687. Epub 2011 Apr 5.


Background: Several factors can affect oocyte quality and therefore pregnancy outcome in assisted reproductive technology (ART) cycles. Recently, a number of studies have shown that the presence of several compounds in the follicular fluid positively correlates with oocyte quality and maturation (i.e., myo-inositol and melatonin).

Aim: In the present study, we aim to evaluate the pregnancy outcomes after the administration of myo-inositol combined with melatonin in women who failed to conceive in previous in vitro fertilization (IVF) cycles due to poor oocyte quality.

Materials and methods: Forty-six women were treated with 4 g/day myo-inositol and 3 mg/day melatonin (inofolic® and inofolic® Plus, Lo.Lipharma, Rome) for 3 months and then underwent a new IVF cycle.

Results: After treatment, the number of mature oocytes, the fertilization rate, the number of both, total and top-quality embryos transferred were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. After treatment, a total of 13 pregnancies occurred, 9 of them were confirmed echographically; four evolved in spontaneous abortion.

Conclusion: The treatment with myo-inositol and melatonin improves ovarian stimulation protocols and pregnancy outcomes in infertile women with poor oocyte quality.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Fertilization in Vitro*
  • Follicle Stimulating Hormone, Human / administration & dosage
  • Humans
  • Infertility, Female / therapy*
  • Inositol / administration & dosage
  • Inositol / pharmacology
  • Inositol / therapeutic use*
  • Longitudinal Studies
  • Melatonin / administration & dosage
  • Melatonin / pharmacology
  • Melatonin / therapeutic use*
  • Oocytes / drug effects*
  • Oocytes / physiology
  • Pregnancy
  • Pregnancy Outcome
  • Prospective Studies
  • Triptorelin Pamoate / administration & dosage


  • Follicle Stimulating Hormone, Human
  • Triptorelin Pamoate
  • Inositol
  • Melatonin