The effect of methylsulfonylmethane on the experimental colitis in the rat

Toxicol Appl Pharmacol. 2011 Jun 15;253(3):197-202. doi: 10.1016/j.taap.2011.03.017. Epub 2011 Apr 2.


Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of MSM in a rat model of experimental colitis. Colitis was induced by intracolonic instillation of 1 ml of 5% of acetic acid. Rats were treated with MSM (400 mg/kg/day, orally) for 4 days. Animals were euthanized and distal colon evaluated histologically and biochemically. Tissue samples were used to measurement of malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), glutathione (GSH) and proinflammatory cytokine (TNF-α and IL-1β) levels. Results showed that MSM decreased macroscopic and microscopic colonic damage scores caused by administration of acetic acid. MSM treatment also significantly reduced colonic levels of MDA, MPO and IL-1β, while increased the levels of GSH and CAT compared with acetic acid-induced colitis group. It seems that MSM as a natural product may have a protective effect in an experimental ulcerative colitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Catalase / metabolism
  • Colitis / drug therapy*
  • Colitis / metabolism
  • Colitis / pathology
  • Dimethyl Sulfoxide / therapeutic use*
  • Glutathione / analysis
  • Interleukin-1beta / analysis
  • Male
  • Malondialdehyde / analysis
  • Peroxidase / metabolism
  • Rats
  • Rats, Wistar
  • Sulfones / therapeutic use*
  • Tumor Necrosis Factor-alpha / analysis


  • Anti-Inflammatory Agents
  • Interleukin-1beta
  • Sulfones
  • Tumor Necrosis Factor-alpha
  • Malondialdehyde
  • dimethyl sulfone
  • Catalase
  • Peroxidase
  • Glutathione
  • Dimethyl Sulfoxide