Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis

J Cyst Fibros. 2011 Sep;10(5):318-25. doi: 10.1016/j.jcf.2011.03.006. Epub 2011 Apr 3.


Background: The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear.

Method: All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2 years without any other chronic Gram-negative infection were matched to two non-infected CF controls.

Results: Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2 years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV(1) compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3 years before the patients became chronically infected.

Discussions: Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Bacterial / blood
  • Child
  • Child, Preschool
  • Chronic Disease
  • Cohort Studies
  • Coinfection
  • Cystic Fibrosis / microbiology*
  • Cystic Fibrosis / physiopathology*
  • Disease Progression
  • Female
  • Gram-Negative Bacterial Infections / diagnosis
  • Gram-Negative Bacterial Infections / microbiology
  • Gram-Negative Bacterial Infections / physiopathology*
  • Humans
  • Male
  • Pneumonia, Bacterial / diagnosis
  • Pneumonia, Bacterial / microbiology
  • Pneumonia, Bacterial / physiopathology*
  • Respiratory Function Tests
  • Stenotrophomonas maltophilia / immunology
  • Stenotrophomonas maltophilia / isolation & purification*
  • Young Adult


  • Antibodies, Bacterial