Acute eosinophilic pneumonia induced by minocycline: prominent Kerley B lines as a feature of positive re-challenge test

Jpn J Med. Mar-Apr 1990;29(2):195-8. doi: 10.2169/internalmedicine1962.29.195.


We report herein a case of acute eosinophilic pneumonia induced by minocycline, confirmed by TBLB and re-challenge test. Re-challenge test suggested that Arthus-type reaction was pathognomonic, and prominent Kerley B lines represented a local hypersensitivity reaction in this patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthus Reaction / chemically induced
  • Arthus Reaction / diagnosis
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology
  • Female
  • Humans
  • Minocycline / adverse effects*
  • Pulmonary Eosinophilia / chemically induced*
  • Pulmonary Eosinophilia / diagnosis
  • Pulmonary Eosinophilia / diagnostic imaging
  • Radiography


  • Minocycline