The prevention of colitis-related cancer by 5-aminosalicylates: an appealing hypothesis that remains unproven

Am J Gastroenterol. 2011 Apr;106(4):737-40. doi: 10.1038/ajg.2011.56.


Whether or not 5-aminosalicylates can prevent colorectal cancer among patients with colitis remains an open question. The observational studies examining this question have provided conflicting results, but none of these studies have been of sufficient quality to provide a definitive answer one way or another.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Colitis / complications*
  • Colitis / drug therapy*
  • Colorectal Neoplasms / etiology*
  • Colorectal Neoplasms / prevention & control*
  • Humans
  • Mesalamine / therapeutic use*
  • Models, Theoretical


  • Anti-Inflammatory Agents, Non-Steroidal
  • Mesalamine