Clamping the clamp of RNA polymerase

EMBO J. 2011 Apr 6;30(7):1190-1. doi: 10.1038/emboj.2011.76.

Abstract

This article highlights the general mechanistic implications for transcriptional elongation based on the crystal structure describing Spt4/5 bound to the RNA polymerase clamp domain from the Cramer lab.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Archaea / chemistry*
  • Chromosomal Proteins, Non-Histone / chemistry*
  • Crystallography, X-Ray
  • DNA-Directed RNA Polymerases / chemistry*
  • Escherichia coli Proteins / chemistry
  • Peptide Elongation Factors / chemistry
  • Protein Structure, Quaternary
  • Transcription Factors / chemistry
  • Transcriptional Elongation Factors / chemistry*

Substances

  • Chromosomal Proteins, Non-Histone
  • Escherichia coli Proteins
  • NusG protein, E coli
  • Peptide Elongation Factors
  • Transcription Factors
  • Transcriptional Elongation Factors
  • SPT5 transcriptional elongation factor
  • DNA-Directed RNA Polymerases