The role of the lignan constituents in the effect of Schisandra chinensis fruit extract on penile erection

Phytother Res. 2011 Dec;25(12):1776-82. doi: 10.1002/ptr.3486. Epub 2011 Apr 6.


The effect of the ethanol extract and active components of the fruit of Schisandra chinensis was evaluated on rabbit penile corpus cavernosum (PCC). PCC, pre-contracted with 10(-5) m phenylephrine (Phe), was treated with extracts of S. chinensis at five different compositions of ethanol and water (95%, 70%, 50%, 30% and ethanol/water [v/v]) and three fractions (0.1, 0.5, 1 and 2 mg/mL). The effect of the extracts and active lignans (schisandrol A and schisandrol B) from S. chinensis on sildenafil citrate pre-incubated PCC was also evaluated. The PCC relaxation induced by the 95% ethanol extraction and the n-hexane fraction was concentration-dependent and the ethanol extract enhanced sildenafil citrate-induced PCC relaxation. The active components of S. chinensis (schisandrol A and schisandrol B) significantly enhanced sildenafil citrate-induced relaxation >2-fold; schisandrol A had the highest relaxant effect on sildenafil citrate pre-incubated PCC. The lignans, schisandrol A and schisandrol B, isolated from the fruits of S. chinensis enhanced sildenafil citrate-induced relaxation and may have synergistic action in patients who do not completely respond to sildenafil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclooctanes
  • Dioxoles
  • Fruit / chemistry
  • In Vitro Techniques
  • Lignans / pharmacology*
  • Male
  • Muscle Relaxation / drug effects*
  • Muscle, Smooth / drug effects
  • Penile Erection / drug effects*
  • Piperazines / pharmacology
  • Plant Extracts / pharmacology*
  • Purines / pharmacology
  • Rabbits
  • Schisandra / chemistry*
  • Sildenafil Citrate
  • Sulfones / pharmacology


  • Cyclooctanes
  • Dioxoles
  • Lignans
  • Piperazines
  • Plant Extracts
  • Purines
  • Sulfones
  • schisandrol A
  • schizandrol B
  • Sildenafil Citrate