In vitro amoebicidal activity of borage (Borago officinalis) extract on Entamoeba histolytica

J Med Food. 2011 Jul-Aug;14(7-8):866-9. doi: 10.1089/jmf.2010.0164. Epub 2011 Apr 10.


Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC₅₀) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC₅₀ of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amebicides / pharmacology*
  • Amebicides / toxicity
  • Animals
  • Artemia / drug effects
  • Borago / chemistry*
  • Chlorocebus aethiops
  • Entamoeba histolytica / drug effects*
  • Inhibitory Concentration 50
  • Lethal Dose 50
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Vero Cells


  • Amebicides
  • Plant Extracts