MicroRNAs and cystic fibrosis--an epigenetic perspective

Cell Biol Int. 2011 May;35(5):463-6. doi: 10.1042/CBI20100664.


CF (cystic fibrosis) is a recessive genetic disease caused by mutations of the CFTR (cystic fibrosis transmembrane conductance regulator), a cAMP-activated anion channel, exhibiting a multitude of clinical manifestations including lung inflammation/infection, pancreatic insufficiency/diabetes, intestinal obstruction and infertility in both sexes. While mutation DF508 is found in 70% of CF patients, large variation in disease phenotypes and severity is observed among the patients. This review discusses current theories accounting for the disease variations and puts forth an epigenetic hypothesis involving microRNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cystic Fibrosis / genetics*
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Epigenesis, Genetic
  • Humans
  • MicroRNAs / genetics*


  • MicroRNAs
  • Cystic Fibrosis Transmembrane Conductance Regulator