Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review

Folia Histochem Cytobiol. 2010 Dec;48(4):597-602. doi: 10.2478/v10042-010-0078-z.


In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Base Sequence
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology*
  • ErbB Receptors / genetics
  • Female
  • Humans
  • Liver Neoplasms / genetics
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary*
  • Middle Aged
  • Molecular Sequence Data
  • Mutation*
  • Neoplasm Metastasis
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins / genetics*


  • KRAS protein, human
  • Proto-Oncogene Proteins
  • ErbB Receptors
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins