Prognostic significance of smac/DIABLO in endometrioid endometrial cancer

Folia Histochem Cytobiol. 2010 Dec;48(4):678-81. doi: 10.2478/v10042-010-0091-2.


Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign.

MeSH terms

  • Aged
  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Endometrial Neoplasms / diagnosis
  • Endometrial Neoplasms / mortality*
  • Endometrial Neoplasms / pathology
  • Female
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Middle Aged
  • Mitochondrial Proteins / metabolism*
  • Prognosis


  • Apoptosis Regulatory Proteins
  • DIABLO protein, human
  • Intracellular Signaling Peptides and Proteins
  • Mitochondrial Proteins