Opsoclonus-myoclonus and anti-Hu positive limbic encephalitis in a patient with neuroblastoma

Pediatr Blood Cancer. 2012 Mar;58(3):472-4. doi: 10.1002/pbc.23131. Epub 2011 Apr 7.


Opsoclonus-myoclonus syndrome (OMS) is seen in 2-3% of children with neuroblastoma and is believed to be caused by an autoimmune process elicited by the tumor. Although long-term neurologic sequelae are common in children with OMS, limbic encephalitis has not previously been reported. We report a child who developed limbic encephalitis associated with anti-Hu antibodies, 6 years after her initial diagnosis of neuroblastoma and OMS. This case demonstrates that patients with neuroblastoma and OMS are at risk for developing new paraneoplastic symptoms years after their original diagnosis and emphasizes the need for careful long-term follow-up.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Female
  • Humans
  • Limbic Encephalitis / drug therapy
  • Limbic Encephalitis / etiology*
  • Limbic Encephalitis / pathology
  • Neuroblastoma / complications*
  • Opsoclonus-Myoclonus Syndrome / drug therapy
  • Opsoclonus-Myoclonus Syndrome / etiology*
  • Opsoclonus-Myoclonus Syndrome / pathology
  • Pelvic Neoplasms / complications*